Topic: Simulation-Based Design Assurance

Replication Counts for Target Precision

Reporting Simulation Assumptions and Results

Reproducible Design Assurance Reports

Random Number Streams for Parallel Simulation

Power Under Clinically Relevant Alternatives

Precision for Rare Safety and Failure Events

Probability of Meeting Multiple Targets

Paired Simulation for Design Comparisons

Pareto Tradeoffs Among Design Objectives

Monte Carlo Error for Means and Quantiles