Topic: Study Design and Optimal Sampling for NLME

Sequential Sampling Design With Updated Information

Sensitivity Equations for NLME Design Calculations

Residual Error and Assay Precision in Design Information

Population and Individual Design Objectives

Marginal Fisher Information in a Random-Intercept Model

Local and Robust Fisher Information Designs

Fisher Information for Population Pharmacokinetic Designs

Fisher-Optimal Designs Under Sampling Constraints

Estimating Variance Components From Replicated Profiles

E-Optimal Designs and Weakly Identified Directions