Topic: Victim and Perpetrator Model Development

Worked Development of a CYP Inducer Model

Worked Development of a Reversible CYP Inhibitor Model

Verifying Perpetrator Single-Drug Pharmacokinetics

Verifying Predicted CYP Interaction Magnitudes

Using Independent Evidence to Challenge a CYP DDI Model

Separating Gut and Liver Contributions to Victim Exposure

Representing Perpetrator Concentrations at CYP Enzyme Sites

Parameterizing Reversible CYP Inhibition from In Vitro Data

Modeling Intestinal CYP3A Inhibition by Oral Perpetrators

Modeling Perpetrators with Both Inhibitory and Inductive Effects