Topic: Victim and Perpetrator Model Development

Implementing Mechanism-Based CYP Inactivation

Extrapolating CYP DDI Models Across Substrates

Estimating CYP Turnover and Recovery After Inhibition

Estimating Fraction Metabolized from Multiple Evidence Sources

Estimating Induction Potency from Probe-Substrate Data

Diagnosing Which Victim Clearance Pathway Drives the DDI

Diagnosing Confounding Between Fraction Metabolized and Inhibitor Potency

Diagnosing DDI Time-Course Mismatch

Decomposing Victim Clearance by CYP Pathway

Constructing Perpetrator Exposure Profiles for CYP Effects