Endocrinology & Metabolism Clinical Trials

Statistical methods in endocrinology & metabolism trials

The methods these trials rely on most, based on the statistical analyses posted to ClinicalTrials.gov, with the tutorial that explains each one.

All endocrinology & metabolism trials

1,009 results

• Renal Effects of Two Iodinated Contrast Media in Patients at Risk Undergoing Computed Tomography: Complete Statistical AnalysisIndependent statistical analysis of Renal Effects of Two Iodinated Contrast Media in Patients at Risk Undergoing Computed Tomography: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…Phase 4Results postedn = 656NCT00209417
• REPLACE-BGIndependent statistical analysis of A Trial Comparing Continuous Glucose Monitoring With and Without Routine Blood Glucose Monitoring in Adults With Type 1 Diabetes: primary endpoint results, effect estimate with confidence interval, sample-size…Phase NAResults postedn = 226NCT02258373
• RESTOREIndependent statistical analysis of A 12 Month Core Study to Assess the Efficacy and Safety of Ranibizumab (Intravitreal Injections) in Patients With Visual Impairment Due to Diabetic Macular Edema and a 24…Phase 3Results postedn = 345NCT00687804
• RETAINIndependent statistical analysis of Efficacy and Safety of Ranibizumab in Two "Treat and Extend" Treatment Algorithms Versus Ranibizumab As Needed in Patients With Macular Edema and Visual Impairment Secondary to Diabetes Mellitus:…Phase 3Results postedn = 373NCT01171976
• RHINEIndependent statistical analysis of A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…Phase 3Results postedn = 951NCT03622593
• SAGB-PMIndependent statistical analysis of Post Implantation/Post Market Evaluation of the Swedish Adjustable Gastric Band: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00543140).Phase 4Results postedn = 303NCT00543140
• SALPIndependent statistical analysis of Pilot Study to Determine Effects of Salsalate in Type 1 Diabetes and Painful Peripheral Neuropathy: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…Phase 2Results postedn = 8NCT01480297
• SAXAPCOSIndependent statistical analysis of Liraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…Phase 3Results postedn = 88NCT03480022
• SMA002Independent statistical analysis of A Clinical Study of the Performance of a Glucose Blinding Protein-Based Continuous Glucose Monitor (GBP CGM): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…Phase 2Results postedn = 16NCT01469715
• SOLO3Independent statistical analysis of Olaparib Treatment in Relapsed Germline Breast Cancer Susceptibility Gene (BRCA) Mutated Ovarian Cancer Patients Who Have Progressed at Least 6 Months After Last Platinum Treatment and Have Received…Phase 3Results postedn = 266NCT02282020
• SOLOIST-WHFIndependent statistical analysis of SOLOIST-WHF (NCT03521934), evaluating sotagliflozin versus placebo in participants with type 2 diabetes and worsening heart failure. Includes trial design, registered endpoints, Cox, ANCOVA and MMRM methodology, reported results,…Phase 3Results postedn = 1,222NCT03521934
• SOMNOSIndependent statistical analysis of Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01503164).Phase NAResults postedn = 111NCT01503164
• SONARIndependent statistical analysis of the phase 3 SONAR trial of atrasentan versus placebo in diabetic nephropathy, including the composite renal endpoint, hazard ratios, confidence intervals, p-values, trial design, and statistical methodology.Phase 3Results postedn = 5,107NCT01858532
• SPARKIndependent statistical analysis of Kuvan® in Phenylketonuria Patients Less Than 4 Years Old: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01376908).Phase 3Results postedn = 56NCT01376908
• SPIRE-1An independent statistical analysis of SPIRE-1 (NCT01975376), the terminated phase 3 placebo-controlled trial of bococizumab for prevention of major cardiovascular events: stratified Cox hazard ratios, MMRM and ANCOVA lipid analyses, multiplicity and…Phase 3Results postedn = 16,784NCT01975376
• SPIRE-2Independent statistical analysis of SPIRE-2 (NCT01975389), the terminated phase 3 placebo-controlled trial of bococizumab in high-risk participants: stratified Cox hazard ratios for major cardiovascular events, MMRM and ANCOVA lipid analyses, and serious…Phase 3Results postedn = 10,564NCT01975389
• SPIRE-HRIndependent statistical analysis of Randomized Clinical Trial Of Bococizumab (PF-04950615; RN316) In Subjects With Hyperlipidemia Or Mixed Dyslipidemia At Risk Of Cardiovascular Events: primary endpoint results, effect estimate with confidence interval, sample-size…Phase 3Results postedn = 711NCT01968954
• STARDUSTIndependent statistical analysis of Liraglutide and Peripheral Artery Disease: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04881110).Phase 4Results postedn = 60NCT04881110
• STEADFASTIndependent statistical analysis of Long-Term Safety Extension Study of ACTIMMUNE® (Interferon γ-1b) in Children and Young Adults With Friedreich's Ataxia: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…Phase 3Results postedn = 38NCT02797080
• STENO-2An independent statistical analysis of STENO-2, a randomized trial of intensified multifactorial intervention in patients with type 2 diabetes and microalbuminuria, including its endpoints, design, planned analyses, and statistical interpretation.Phase NAn = 160NCT00320008
• STEP 4Independent statistical analysis of STEP 4 (NCT03548987), a randomized phase 3 trial evaluating change in body weight with semaglutide 2.4 mg versus placebo in people with overweight or obesity.Phase 3Results postedn = 902NCT03548987
• STEP 5Complete statistical analysis of the STEP 5 phase 3 trial of semaglutide versus placebo in adults with overweight or obesity, including trial design, primary endpoints, ANCOVA, MMRM, logistic regression, confidence intervals, and…Phase 3Results postedn = 304NCT03693430
• STEP UPComplete statistical analysis of the STEP UP phase 3 trial of semaglutide 7.2 mg versus placebo in people with obesity, including trial design, primary endpoints, ANCOVA, odds ratios, confidence intervals, p-values, safety,…Phase 3Results postedn = 1,407NCT05646706
• STEP12Independent statistical analysis of A Research Study to See How Well Semaglutide Helps People Who Have a Body Weight Above the Healthy Weight Range: primary endpoint results, effect estimate with confidence interval,…Phase 3Results postedn = 242NCT06041217
• STOP-NIDDMIndependent statistical analysis of STOP-NIDDM, a randomized phase 3 trial evaluating acarbose versus placebo for incidence of newly diagnosed type 2 diabetes in participants with metabolic syndrome.Phase 3n = 1,429NCT00629213
• SURMOUNT-3Independent statistical analysis of the phase 3 SURMOUNT-3 trial of tirzepatide in participants with obesity or overweight after a lifestyle weight loss program, including trial design, primary endpoints, reported estimates, statistical methods,…Phase 3Results postedn = 579NCT04657016
• SURMOUNT-CNIndependent statistical analysis of A Study of Tirzepatide (LY3298176) in Chinese Participants Without Type 2 Diabetes Who Have Obesity or Overweight (SURMOUNT-CN): primary endpoint results, effect estimate with confidence interval, sample-size planning…Phase 3Results postedn = 210NCT05024032
• SURMOUNT-MMOIndependent statistical analysis of SURMOUNT-MMO, a randomized phase 3 study of tirzepatide versus placebo in adults with obesity or overweight, including its composite time-to-event endpoint, design, planned analysis, and statistical interpretation.Phase 3n = 15,374NCT05556512
• SURMOUNT-OSAIndependent statistical analysis of SURMOUNT-OSA, a randomized phase 3 trial of tirzepatide in participants with obstructive sleep apnea and obesity, including AHI results, ANCOVA, logistic regression, confidence intervals, and safety.Phase 3Results postedn = 469NCT05412004
• SURPASS-4Independent statistical analysis of SURPASS-4, a randomized phase 3 trial of once-weekly tirzepatide versus once-daily insulin glargine in participants with type 2 diabetes and increased cardiovascular risk.Phase 3Results postedn = 2,002NCT03730662
• SURPASS-6Independent statistical analysis of A Study of Tirzepatide (LY3298176) Versus Insulin Lispro (U100) in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine (U100) With or Without Metformin: primary endpoint results,…Phase 3Results postedn = 1,428NCT04537923
• SUSTAINIndependent statistical analysis of Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin in Subjects With Type 2 Diabetes (SUSTAIN - CHINA MRCT): primary endpoint results, effect estimate…Phase 3Results postedn = 868NCT03061214
• SUSTAIN 11Complete statistical analysis of SUSTAIN 11, a randomized phase 3 trial comparing semaglutide with insulin aspart when added to metformin and insulin glargine in people with type 2 diabetes.Phase 3Results postedn = 2,274NCT03689374
• SUSTAIN-7Independent statistical analysis of the SUSTAIN-7 phase 3 trial comparing semaglutide with dulaglutide as add-on to metformin in subjects with type 2 diabetes, including mixed-effects modeling, non-inferiority and superiority testing, confidence intervals,…Phase 3Results postedn = 1,201NCT02648204
• SUSTAIN™ 2Complete statistical analysis of SUSTAIN™ 2, a randomized phase 3 trial comparing once-weekly semaglutide with once-daily sitagliptin as add-on therapy in subjects with type 2 diabetes.Phase 3Results postedn = 1,231NCT01930188
• SUSTAIN™ 5Independent statistical analysis of Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to Basal Insulin Alone or Basal Insulin in Combination With Metformin in Subjects With Type 2 Diabetes: primary…Phase 3Results postedn = 397NCT02305381
• SWITCH 2Independent statistical analysis of A Trial Comparing the Safety and Efficacy of Insulin Degludec and Insulin Glargine, With or Without OADs in Subjects With Type 2 Diabetes: primary endpoint results, effect estimate…Phase 3Results postedn = 721NCT02030600
• SWITCH PROIndependent statistical analysis of A Research Study to Compare the Effect of Insulin Degludec and Insulin Glargine on Blood Sugar Levels in People With Type 2 Diabetes - the SWITCH PRO Study:…Phase 4Results postedn = 498NCT03687827
• T-jet®Independent statistical analysis of Comparison of a Needle-free Injection Method With a Needle-syringe Injection Method: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase 4Results postedn = 52NCT00990340
• T1GERIndependent statistical analysis of A Study of SIMPONI® to Arrest Beta-cell Loss in Type 1 Diabetes: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…Phase 2Results postedn = 84NCT02846545
• T2D_MTUIndependent statistical analysis of Impact of Muscle and Tendon Dysfunction in People With Type 2 Diabetes Mellitus: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…Phase NAResults postedn = 46NCT05585502
• TACTiCComplete statistical analysis of the TACTiC phase 3 trial of 5 mg rosuvastatin calcium with a Web App in consumers with high cholesterol, including endpoint definitions, reported estimates, confidence intervals, statistical methodology,…Phase 3Results postedn = 1,196NCT04964544
• TANGOIndependent statistical analysis of CER-001 Therapy as a Novel Approach to Treat Genetic Orphan Diseases: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase 3Results postedn = 30NCT02697136
• TAZPOWERIndependent statistical analysis of A Trial to Evaluate Safety, Tolerability and Efficacy of Elamipretide in Subjects With Barth Syndrome: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…Phase 2/3Results postedn = 12NCT03098797
• THRIVEIndependent statistical analysis of Observational Study That Will Collect Information on Patients With Urea Cycle Disorders (UCDs): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…Phase NAResults postedn = 203NCT01948427
• TN07Independent statistical analysis of Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…Phase 3Results postedn = 560NCT00419562
• TRFIndependent statistical analysis of Effects of a Supplement Derived From Palm Oil on Cholesterol Levels in the Blood: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…Phase 3Results postedn = 13NCT02634606
• trinkfitIndependent statistical analysis of Promoting Water Consumption for Prevention of Overweight in School Children in a Controlled Intervention Trial: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…Phase NAResults postedn = 2,950NCT00554294
• TRISTANAn independent statistical analysis of the TRISTAN trial (NCT04650152), evaluating Tricor fenofibrate therapy effectiveness in patients with metabolic syndrome and hypertriglyceridemia.n = 1,000NCT04650152
• TRIUMPH-2Independent statistical analysis of TRIUMPH-2, a randomized, double-blind phase 3 study of retatrutide in participants with type 2 diabetes mellitus who have obesity or overweight.Phase 3n = 1,152NCT05929079

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