Statistical methods in infectious disease trials
The methods these trials rely on most, based on the statistical analyses posted to ClinicalTrials.gov, with the tutorial that explains each one.
Non-inferiority trial design
Risk difference
Cochran-Mantel-Haenszel test
ANCOVA
Hazard ratio
Score-based CI for proportions (Miettinen-Nurminen, Newcombe, Wilson)
Fisher exact test
Odds ratio
All infectious disease trials
903 results
- Pharmacokinetics and Safety of SAR441236: Complete Statistical AnalysisIndependent statistical analysis of Pharmacokinetics and Safety of SAR441236: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03705169).
- Pharmacokinetics of Daptomycin During Cardiopulmonary Bypass Surgery: Complete Statistical AnalysisIndependent statistical analysis of Pharmacokinetics of Daptomycin During Cardiopulmonary Bypass Surgery: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00701636).
- Pharmacokinetics of Gepotidacin Tablets in Adults and Adolescents Subjects: Complete Statistical AnalysisIndependent statistical analysis of Pharmacokinetics of Gepotidacin Tablets in Adults and Adolescents Subjects: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04079790).
- Pharmacokinetics of MK-3682B in Participants With Moderate to Severe Renal Insufficiency (MK-3682B-030): Complete Statistical AnalysisIndependent statistical analysis of Pharmacokinetics of MK-3682B in Participants With Moderate to Severe Renal Insufficiency (MK-3682B-030): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…
- Pharmacokinetics of Plasma Doravirine Once Daily Over 72 Hours Following Drug Intake Cessation in Healthy Volunteers: Complete Statistical AnalysisIndependent statistical analysis of Pharmacokinetics of Plasma Doravirine Once Daily Over 72 Hours Following Drug Intake Cessation in Healthy Volunteers: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- Pharmacokinetics of Retapamulin in Pediatric Subjects With Uncomplicated Skin Infections.: Complete Statistical AnalysisIndependent statistical analysis of Pharmacokinetics of Retapamulin in Pediatric Subjects With Uncomplicated Skin Infections.: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00555061).
- Phase 1 Clinical Trial of Single-Vial ID93 + GLA-SE in Healthy Adults: Complete Statistical AnalysisIndependent statistical analysis of Phase 1 Clinical Trial of Single-Vial ID93 + GLA-SE in Healthy Adults: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…
- Phase 1 Study of PBTZ169: Complete Statistical AnalysisIndependent statistical analysis of Phase 1 Study of PBTZ169: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03036163).
- Phase 1 Trial of a Malaria Vaccine in Young Kenyan Children: Complete Statistical AnalysisIndependent statistical analysis of Phase 1 Trial of a Malaria Vaccine in Young Kenyan Children: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…
- Phase 1/2 Study of TAK-850 Intramuscular Injection in Healthy Pediatric Participants: Complete Statistical AnalysisIndependent statistical analysis of Phase 1/2 Study of TAK-850 Intramuscular Injection in Healthy Pediatric Participants: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…
- Phase 1b Dose Escalation Study of Intravenous JX-594 in Metastatic, Refractory Colorectal Carcinoma: Complete Statistical AnalysisIndependent statistical analysis of Phase 1b Dose Escalation Study of Intravenous JX-594 in Metastatic, Refractory Colorectal Carcinoma: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…
- Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies: Complete Statistical AnalysisIndependent statistical analysis of Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection: Complete Statistical AnalysisIndependent statistical analysis of Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection: primary endpoint results, effect estimate with confidence interval,…
- Phase I Clinical Trial for Comparison of Pharmacokinetic Characteristics of Vorico Injection 200mg(Voriconazole) and Vfend® IV 200mg for Single Dose Crossover Intravenous Infusion in Healthy Volunteers: Complete Statistical AnalysisIndependent statistical analysis of Phase I Clinical Trial for Comparison of Pharmacokinetic Characteristics of Vorico Injection 200mg(Voriconazole) and Vfend® IV 200mg for Single Dose Crossover Intravenous Infusion in Healthy Volunteers: primary endpoint…
- Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE®: Complete Statistical AnalysisIndependent statistical analysis of Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE®: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01827371).
- Phase IIa Clinical Study of Recombinant Mycobacterium Tuberculosis Allergen ESAT6-CFP10: Complete Statistical AnalysisIndependent statistical analysis of Phase IIa Clinical Study of Recombinant Mycobacterium Tuberculosis Allergen ESAT6-CFP10: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT02329730).
- PHOMICIndependent statistical analysis of Effect of Photodynamic Treatment on Skin Microbiome. Single Center Study: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04067843).
- PICASSOIndependent statistical analysis of A Study to Learn About the Safety and Immune Activity of RSVpreF in Children 2 to
- PiiitchIndependent statistical analysis of Feasibility of Cocooning Immunization Strategy With Influenza Vaccine: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00570037).
- PIIPPIIndependent statistical analysis of COVID-19: Povidone-Iodine Intranasal Prophylaxis in Front-line Healthcare Personnel and Inpatients: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04364802).
- Pilot Study of Adding Raltegravir (MK-0518) to Antiretroviral Therapy in Patients With Low Level Viremia: Complete Statistical AnalysisIndependent statistical analysis of Pilot Study of Adding Raltegravir (MK-0518) to Antiretroviral Therapy in Patients With Low Level Viremia: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…
- PinPointe FootLaser for the Treatment of Onychomycosis: Complete Statistical AnalysisIndependent statistical analysis of PinPointe FootLaser for the Treatment of Onychomycosis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00935649).
- Pioglitazone to Treat Fatty Liver in People With HIV Infection: Complete Statistical AnalysisIndependent statistical analysis of Pioglitazone to Treat Fatty Liver in People With HIV Infection: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00441272).
- PITCH-EIndependent statistical analysis of Pain Inflammation and Cannabis in HIV: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT05554146).
- PIVOTIndependent statistical analysis of the PIVOT randomized phase 4 trial evaluating protease inhibitor monotherapy versus ongoing triple-therapy in the long term management of HIV infection.
- Pivotal, Multicenter, Observer-Blind, Randomized Study of Influenza A (H1N1)2009 Monovalent Subunit Vaccine With and Without Adjuvant in Children Ages 6 to <36 Months: Complete Statistical AnalysisIndependent statistical analysis of Pivotal, Multicenter, Observer-Blind, Randomized Study of Influenza A (H1N1)2009 Monovalent Subunit Vaccine With and Without Adjuvant in Children Ages 6 to
- Placebo Controlled, Dose Response, Safety and Immunogenicity Study of Vesicular Stomatitis Virus (VSV) Ebola Vaccine in Healthy Adults (V920-004): Complete Statistical AnalysisIndependent statistical analysis of Placebo Controlled, Dose Response, Safety and Immunogenicity Study of Vesicular Stomatitis Virus (VSV) Ebola Vaccine in Healthy Adults (V920-004): primary endpoint results, effect estimate with confidence interval, sample-size…
- Placebo-Controlled Trial of Antibiotic Therapy in Adults With Suspect Lower Respiratory Tract Infection (LRTI) and a Procalcitonin Level: Complete Statistical AnalysisIndependent statistical analysis of Placebo-Controlled Trial of Antibiotic Therapy in Adults With Suspect Lower Respiratory Tract Infection (LRTI) and a Procalcitonin Level: primary endpoint results, effect estimate with confidence interval, sample-size planning…
- Plan and Pledge, HIV Self-testing in South Africa: Complete Statistical AnalysisIndependent statistical analysis of Plan and Pledge, HIV Self-testing in South Africa: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03898557).
- Plasma Therapy of COVID-19 in Severely Ill Patients: Complete Statistical AnalysisIndependent statistical analysis of Plasma Therapy of COVID-19 in Severely Ill Patients: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04359810).
- Plasmodium Vivax Efficacy Trial in Cruzeiro do Sul, Acre, Brazil: Complete Statistical AnalysisIndependent statistical analysis of Plasmodium Vivax Efficacy Trial in Cruzeiro do Sul, Acre, Brazil: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT02043652).
- Plerixafor and Filgrastim For Mobilization of Donor Peripheral Blood Stem Cells Before A Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies: Complete Statistical AnalysisIndependent statistical analysis of Plerixafor and Filgrastim For Mobilization of Donor Peripheral Blood Stem Cells Before A Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies: primary endpoint results,…
- PLUSIndependent statistical analysis of Improving HIV and Alcohol-Related Outcomes Among HIV+ Persons in Clinic Settings: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…
- pNAATIndependent statistical analysis of Performance of Nucleic Acid Amplification Tests for the Detection of NG and CT: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…
- Pneumococcal Vaccine Booster Study in Healthy Children 12-18 Mths Old Previously Primed With the Same Vaccines: Complete Statistical AnalysisIndependent statistical analysis of Pneumococcal Vaccine Booster Study in Healthy Children 12-18 Mths Old Previously Primed With the Same Vaccines: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- Poly-ICLCIndependent statistical analysis of Enhancement by Poly-ICLC During HIV-1 Infection: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT02071095).
- POPPiIndependent statistical analysis of Improving Uptake and Adherence to HIV Prevention Services With Pre-exposure Prophylaxis (PrEP), HIV Self- Testing and Adherence Support for Very High Risk HIV-negative Young Women Aged 15-24 in…
- Post-authorisation Passive Enhanced Safety Surveillance of Seasonal Influenza Vaccines: Pilot Study in England: Complete Statistical AnalysisIndependent statistical analysis of Post-authorisation Passive Enhanced Safety Surveillance of Seasonal Influenza Vaccines: Pilot Study in England: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…
- Post-licensure, Modified Double-blind, Multi-center Study Evaluating Safety and Immunogenicity of ADACEL® and BOOSTRIX®: Complete Statistical AnalysisIndependent statistical analysis of Post-licensure, Modified Double-blind, Multi-center Study Evaluating Safety and Immunogenicity of ADACEL® and BOOSTRIX®: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…
- Post-marketing Surveillance Study of Invasive Mycosis With Posaconazole (Study P04641): Complete Statistical AnalysisIndependent statistical analysis of Post-marketing Surveillance Study of Invasive Mycosis With Posaconazole (Study P04641): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00726609).
- POTENTE Study: A Study of Early Virological Response in Naive Patients With Chronic Hepatitis C, Genotype 2 or 3, Treated With PEGASYS (Peginterferon Alfa-2a (40KD)) Plus Copegus (Ribavirin).: Complete Statistical AnalysisIndependent statistical analysis of POTENTE Study: A Study of Early Virological Response in Naive Patients With Chronic Hepatitis C, Genotype 2 or 3, Treated With PEGASYS (Peginterferon Alfa-2a (40KD)) Plus Copegus (Ribavirin).:…
- Potential for Drug-drug Interactions Between Boceprevir and Etravirine in HIV/Hepatitis C Virus Negative Volunteers: Complete Statistical AnalysisIndependent statistical analysis of Potential for Drug-drug Interactions Between Boceprevir and Etravirine in HIV/Hepatitis C Virus Negative Volunteers: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…
- Potential Influence of Esomeprazole on the Pharmacokinetics of Pritelivir: Complete Statistical AnalysisIndependent statistical analysis of Potential Influence of Esomeprazole on the Pharmacokinetics of Pritelivir: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT05513625).
- PPVIndependent statistical analysis of HPV Vaccination Study in Postpartum Women: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04274153).
- PPVPIndependent statistical analysis of Impact and Cost of a Pharmacist Pneumococcal Vaccination Program With PNEUMOVAX® 23 at an Urban Senior Center: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…
- PRACTICEIndependent statistical analysis of Package of Resources for Assisted Contact Tracing: Implementation, Costs, and Effectiveness: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…
- PRECAUTIONIndependent statistical analysis of Prevention of Catheter-Associated Urinary Tract Infection in Incontinence and Reconstructive Pelvic Surgery Patients: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…
- PrEP iT!Independent statistical analysis of PrEP iT! Mobile App Intervention: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04509076).
- PrEP ProIndependent statistical analysis of Multi-component Intervention to Train Providers to Promote PrEP for Girls and Women in the Deep South: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- PREPAREIndependent statistical analysis of Pre-operative Alcohol Skin Solutions in Fractured Extremities: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03523962).