Topic: Biological Plausibility and Parameter Uncertainty

Plausibility-Constrained Sampling of Parameter Sets

Physiological Bounds on Tissue Composition Fractions

Physiologically Implausible Parameter Compensation

Nonlinear Responses to Uncertain Inputs

Measurement Error, Biological Variability, and Knowledge Uncertainty

Lognormal Distributions for Positive PBPK Parameters

Joint Constraints on Organ Volumes and Blood Flows

First-Order Uncertainty Propagation with the Delta Method

Expert Elicitation for Unmeasured PBPK Inputs

Epistemic Uncertainty Versus Interindividual Variability