Topic: The Estimand Framework and Intercurrent Events

Population-Level Summaries and Treatment Contrasts

Principal-Stratum Estimands

Operational Definitions of Intercurrent Events

Ordering Composite Outcomes With Death

Outcomes Measured After an Intercurrent Event

Missingness After Treatment Discontinuation

Mixed Strategies for Multiple Events

Nonadherence and Dose Modification

Missing Data Within a Defined Estimand

Intercurrent Events Versus Missing Outcomes