Topic: The Estimand Framework and Intercurrent Events

Interpreting While-on-Treatment Effects

Hypothetical Estimands

Identification of Hypothetical Estimands

Event Timing in Longitudinal Estimands

Estimand, Estimator, and Estimate

Estimand Populations and Generalizability

Estimand Specification Tables for Trials

Estimands as Clinical Questions

Estimands Under Different Treatment Conditions

Estimator Alignment for Treatment-Policy Questions