Introduction
A stronger encouragement can reach more people, but it can also require more staff time, money, or contact. Choosing an intensity therefore involves more than asking which arm produced the highest uptake. The relevant decision is which feasible offer best serves the policy objective, given the outcomes it produces and the resources it uses.
The key distinction is between the effect of offering an encouragement intensity and the effect of receiving treatment. A randomized comparison of encouragement arms can estimate the former, along with each arm’s uptake and implementation cost. Higher uptake alone does not establish that treatment caused an outcome improvement.
What Is Compared Across Intensities?
Suppose people are randomly assigned to one of several encouragement arms, indexed by \(z\). Let \(z=0\) denote a reference arm, such as usual information, and let larger values represent more intensive offers. Let \(D\) indicate whether a person takes up the treatment, and let \(Y\) be an outcome measured on a defined scale. For each person, \(D(z)\) is the uptake that would occur under assignment to arm \(z\), and \(Y(z)\) is the outcome that would occur under that assignment. The latter includes all consequences of the offer, whether or not the person takes up treatment.
Let \(C(z)\) denote the implementation cost associated with assigning one person to arm \(z\), measured on a consistent accounting basis. The mean cost per assigned person is \(E[C(z)]\). It is important to specify the denominator: a per-person-assigned cost includes people who do not take up treatment, while a cost per treated person does not. For comparing offers as policies, cost per person assigned is often the more direct quantity.
A valid randomized comparison requires that assignment to the encouragement arms is genuinely random, that the observed outcome and uptake for each person correspond to their assigned arm, and that one person’s assignment does not change another person’s outcome or uptake. Under these conditions, arm-specific sample means estimate the corresponding mean potential outcomes. Randomization identifies the assignment effects even if some people do not take up treatment and even if the encouragement itself can affect outcomes by pathways other than treatment receipt.
To see why, random assignment makes \(Z\) independent of the potential outcomes, so \(E[Y(z)\mid Z=z]=E[Y(z)]\) and \(E[Y(0)\mid Z=0]=E[Y(0)]\). Consistency means that the observed outcome is the potential outcome under the assigned arm: \(Y=Y(Z)\). Thus the observed difference in arm means equals the assignment effect. The same reasoning applies to uptake and, when costs are well-defined under assignment, to costs.
Worked Example: Comparing Three Randomized Offers
In a hypothetical trial, 200 people are assigned to each of three arms: a reference information offer, a low-intensity encouragement, or a high-intensity encouragement. Uptake is the proportion who begin the offered treatment. The outcome is a health score for which higher values are better. Mean implementation cost is recorded per person assigned.
| Assigned arm | Mean outcome score | Uptake rate | Mean cost per person assigned |
|---|---|---|---|
| Reference | 50.0 points | 0.20 | $0 |
| Low intensity | 52.0 points | 0.45 | $8 |
| High intensity | 53.5 points | 0.70 | $20 |
Relative to the reference arm, the low-intensity assignment effect is \(52.0-50.0=2.0\) points, and its uptake difference is \(0.45-0.20=0.25\), or 25 percentage points. Its incremental implementation cost is \(\$8-\$0=\$8\) per person assigned.
For the high-intensity arm, the assignment effect is \(53.5-50.0=3.5\) points, the uptake difference is \(0.70-0.20=0.50\), or 50 percentage points, and the incremental cost is \(\$20-\$0=\$20\) per person assigned. Comparing high with low intensity gives \(53.5-52.0=1.5\) additional outcome points, \(0.70-0.45=0.25\), or 25 percentage points, more uptake, and \(\$20-\$8=\$12\) additional cost per person assigned.
These are randomized assignment comparisons. The 25-percentage-point increase in uptake from low to high intensity does not mean that treatment improves the health score by 1.5 points, nor does the 3.5-point high-versus-reference outcome difference estimate the effect of treatment receipt. They estimate the consequences of assigning each offer.
Feasibility Before Preference
A decision rule should state constraints before selecting an arm. For example, a program may require uptake of at least a specified level and limit mean implementation cost per person assigned. An arm is feasible only if it satisfies every required constraint. Among feasible arms, the decision-maker can then apply a stated objective, such as choosing the largest assignment effect on the outcome.
This separates two questions. Feasibility asks whether an intensity meets operational requirements. Preference asks which feasible intensity is best according to the policy objective. A high-uptake arm can fail a cost ceiling; a low-cost arm can fail a minimum-uptake requirement. Neither should be declared best based on one metric alone.
Worked Example: Applying Uptake and Cost Constraints
Use the hypothetical trial results above. Suppose the program requires uptake of at least 40% and mean implementation cost no greater than $15 per person assigned. Among arms satisfying both constraints, the program seeks the largest mean outcome score.
The reference arm has uptake \(0.20\), which is below \(0.40\), so it is infeasible even though its cost is within the ceiling. The low-intensity arm has uptake \(0.45\geq0.40\) and cost \(\$8\leq\$15\), so it is feasible. The high-intensity arm meets the uptake requirement, \(0.70\geq0.40\), but its cost of $20 exceeds the ceiling, so it is infeasible.
The low-intensity arm is the only feasible option and therefore the choice under this rule. This conclusion does not say it has the largest outcome effect overall: the high-intensity arm has the largest observed mean outcome score, but it violates the stated cost constraint. If the cost ceiling changed, the choice might change as well.
Comparing Feasible Options With a Valued Outcome
Sometimes more than one arm meets all constraints. A decision-maker may then specify how much an outcome improvement is worth relative to cost. This requires an explicit value and compatible units; it cannot be inferred from uptake rates. For example, if one outcome point is assigned a value of $10 per person, a simple incremental net benefit relative to the reference arm is that value multiplied by the assignment effect, minus incremental cost per person assigned.
Here \(v\) is the decision-maker’s stated monetary value per outcome point. This calculation is meaningful only if the outcome scale, time horizon, and cost accounting are appropriate to the decision. It is a decision criterion for encouragement policies, not an estimate of the treatment effect.
Worked Example: Net Benefit Under an Explicit Valuation
Suppose the hypothetical program can afford either the low- or high-intensity arm, and it values a one-point increase in the mean health score at $10 per person over the specified follow-up period. Use the reference arm as the comparison, with zero incremental cost.
For low intensity, the valued outcome difference is \(2.0\text{ points}\times \$10\text{ per point}=\$20\) per person. Subtract its incremental cost: \(\$20-\$8=\$12\) net benefit per person assigned.
For high intensity, the valued outcome difference is \(3.5\text{ points}\times \$10\text{ per point}=\$35\) per person. Subtract its incremental cost: \(\$35-\$20=\$15\) net benefit per person assigned. Under this particular valuation and cost definition, high intensity has the greater estimated net benefit, by \(\$15-\$12=\$3\) per person assigned.
The conclusion depends on the stated $10 valuation, the estimated assignment effects, and the cost figures. It does not follow from high intensity’s greater uptake, and it is not a claim that treatment receipt itself generates $15 of benefit.
What Uptake Can and Cannot Tell You
Uptake is an important implementation outcome. It tells a program how many people start treatment under each offer and helps assess reach, staffing, and capacity. But a change in uptake is a change in an intermediate response to assignment, not an outcome effect. People induced to take up treatment may differ from those who would take it up under either offer, and the encouragement could also affect the measured outcome through other pathways.
A treatment-effect interpretation requires additional causal assumptions beyond random assignment to the encouragement. In particular, translating an assignment contrast into a treatment-receipt effect generally depends on assumptions about whether the encouragement affects the outcome only through treatment and about how uptake responds to assignment. The assignment-effect comparison presented here does not require that interpretation. If the decision concerns which offer to implement, the randomized assignment effect is often directly relevant precisely because it includes all consequences of implementing that offer.
One can also report the cost per additional person taking up treatment, calculated as the incremental cost divided by the incremental uptake proportion. For the high-versus-low comparison above, this is \(\$12/0.25=\$48\) per additional person taking up treatment. This is an implementation ratio, not a cost per person whose outcome improved, and not a treatment-effect estimate. It can be unstable when the uptake difference is small, so it should be reported alongside the separate cost and uptake differences.
Uncertainty and Practical Selection
Arm means, uptake proportions, and costs are estimated from data, so a decision based on their point estimates can be uncertain. A result just meeting a minimum-uptake threshold may not reliably meet it in a new implementation. Likewise, apparent differences in mean outcomes across arms may be imprecise. Decision-makers should examine uncertainty in the quantities that determine feasibility and preference, and should specify in advance how uncertainty affects the rule—for example, whether feasibility is judged by a point estimate or by a conservative confidence bound.
The randomized design supports causal interpretation of arm comparisons only if assignment was implemented as planned and outcome measurement and follow-up are sufficiently complete for the target comparison. Differential missing outcomes, deviations in assignment, or spillovers between participants can undermine a simple comparison of observed arm means. Cost estimates also need a common perspective and time horizon: comparing direct delivery costs in one arm with total program costs in another would not be a coherent ranking.
Specify the outcome, the reference arm, the target population, the cost perspective, and the time horizon.
For each intensity, report assignment effects on outcomes, uptake differences, and incremental implementation costs, with uncertainty where available.
Mark an arm feasible only when it meets every prespecified uptake, cost, or operational requirement.
Use the stated outcome objective or an explicitly valued net-benefit criterion. Do not use uptake alone as a proxy for treatment benefit.
Common Mistake
Wrong reasoning: “The high-intensity arm increased uptake by 25 percentage points compared with the low-intensity arm, so treatment caused a 25-percentage-point improvement in health.”
This confuses an uptake difference with an outcome effect. Uptake is whether people began treatment; health is a separate outcome. The correction is to report each randomized contrast in its own units: here, high versus low intensity increased uptake by 25 percentage points, increased the mean health score by 1.5 points, and increased implementation cost by $12 per person assigned. Those figures describe the effect of assigning the higher-intensity offer, not the effect of receiving treatment.
Check Your Understanding
Answer these questions using the distinctions and decision rules developed above.
- An arm has a higher uptake rate than the reference arm but the same mean outcome. What does the randomized comparison establish about the offer, and what does it not establish about treatment receipt?
- A program requires uptake of at least 50% and cost no greater than $12 per person assigned. An arm has uptake of 0.55 and cost of $13. Is it feasible? Explain.
- Why is a cost-per-additional-uptake ratio not the same as a cost per health improvement?
- If two feasible arms have different assignment effects and costs, what additional information is needed to calculate net benefit?
- State two assumptions that support interpreting randomized arm mean differences as assignment effects.