Why Compare Interrupted Trajectories?
An outcome can change after an intervention for reasons unrelated to the intervention: a secular trend, a seasonal fluctuation, or a shock that affects both treated and untreated units. A simple before-and-after comparison in the treated group cannot separate these explanations from a treatment effect. A control series helps by showing how outcomes changed over the same calendar time without the intervention.
The comparative interrupted time-series (CITS) contrast compares the treated group’s pre-to-post change with the control group’s change over that same interval. Its causal interpretation depends not on the two groups having identical outcome levels, but on a more specific counterfactual claim: without the intervention, their outcome changes would have been comparable.
For clarity, write \(\bar Y_{G,t}\) for the observed mean outcome in group \(G\) at time \(t\). If treatment starts after baseline time \(s\), then under consistency and no anticipation, the treated group’s observed mean at \(s\) is its untreated mean, while its observed mean at post-intervention time \(t\) is its treated mean. The control group is observed without intervention at both times. The contrast is therefore
The first parenthesis is the treated group’s observed change; the second is the control group’s observed change. Subtracting the latter removes the change that serves as an estimate of what the treated group would have experienced without the intervention, provided the identification condition below is credible.
The Identification Condition
The causal target at post-intervention time \(t\) is the treated group’s average effect at that time: its mean outcome under the intervention minus its mean outcome if it had not received the intervention. In potential-outcomes notation, this is
The difficulty is that \(Y_{T,t}(0)\), the treated group’s post-intervention outcome without the intervention, is unobserved. The control group can stand in for the missing untreated change only under an assumption about how the two groups would have changed.
Under consistency, no anticipation, an untreated control group, and this parallel-untreated-trends condition, the CITS contrast identifies \(\tau_t\). The algebra shows exactly why.
The first equality uses the observed outcomes implied by the design: treated units have untreated outcomes at baseline and treated outcomes after the intervention, while controls remain untreated. The second equality adds and subtracts the treated group’s unobserved untreated post-intervention mean. The bracketed term is the difference between the groups’ untreated changes; the identification condition sets that term to zero. The remaining term is the treated group’s average effect at time \(t\).
Worked Example: A Difference in Changes
Suppose a hypothetical policy begins in one region after the baseline measurement. The outcome is the monthly number of preventable hospital admissions per 10,000 residents. The treated region’s mean is 50 at baseline and 44 after the policy; a control region’s mean is 40 at baseline and 38 after the same calendar interval. Assume the intervention was not anticipated, the control region remained untreated, and the regions would have had comparable untreated changes.
The treated region’s change is \(44-50=-6\) admissions per 10,000 residents. The control region’s change is \(38-40=-2\) admissions per 10,000 residents. Thus,
Under the stated identification assumptions, the estimated effect is a reduction of 4 preventable admissions per 10,000 residents over the comparison interval, relative to what the treated region would have experienced without the policy. The groups started at different levels, but that does not invalidate this comparison: the calculation concerns changes, and the assumed counterfactual condition concerns comparable changes.
Assumptions That Give the Contrast a Causal Meaning
The arithmetic can always be carried out; causal identification depends on the design and assumptions. The parallel-untreated-trends condition is central, but several related conditions are needed to connect observed data to the potential outcomes in the derivation.
- Consistency and a well-defined intervention. The observed outcome for a treated group after intervention corresponds to the potential outcome under the intervention regime, and the observed outcome under no intervention corresponds to the untreated potential outcome. The intervention and its start time must be sufficiently well specified for these outcomes to be meaningful.
- No anticipation. Before the intervention begins, the treated group’s outcomes are not already affected by expecting it. If behavior changes in advance, a supposedly untreated baseline may already reflect the intervention.
- The control remains untreated and is not affected by treatment. The control series must represent outcomes under no intervention. Direct exposure, spillovers from treated units, or a related policy applied only to the control can make it a poor representation of the untreated trajectory.
- Comparable untreated changes. Had the intervention not occurred, the treated and control groups would have experienced the same mean change over the relevant interval. The condition need not hold for observed, treated outcomes after intervention; it concerns the counterfactual outcomes under no intervention.
- No differential concurrent shock that substitutes for the intervention. If another event at the intervention date affects only the treated group, the contrast combines that event’s effect with the intervention effect. A shared shock may cancel in the comparison, but a group-specific shock generally will not.
- Comparable measurement and group composition. Changes in outcome definitions, recording practices, or which units contribute to each group’s mean can create apparent changes unrelated to the intervention. The measured outcome should be comparable across groups and time.
Worked Example: When Differential Untreated Trends Bias the Contrast
Consider a hypothetical employment program. Before the program, employment is 50% in the treated area and 40% in a control area. Afterward, the observed rates are 59% and 44%, respectively. Suppose that, without the program, employment in the treated area would have risen to 56% because of a local economic recovery. This hypothetical untreated increase is 6 percentage points, whereas the control area’s increase is 4 percentage points.
The observed treated change is \(59\%-50\%=9\) percentage points. The control change is \(44\%-40\%=4\) percentage points. The CITS contrast is
But the treated area’s actual effect, under the stipulated hypothetical counterfactual, is \(59\%-56\%=3\) percentage points. The contrast exceeds that effect by 2 percentage points because the treated area would have improved 2 percentage points more than the control area even without the program:
Thus the observed contrast equals the effect plus the difference in untreated changes: \(5=3+2\) percentage points. If the differential untreated change is not zero, the CITS contrast does not, by itself, isolate the program’s effect.
Several Post-Intervention Times
When outcomes are observed at several post-intervention times, a CITS contrast can be calculated separately for each time using a specified pre-intervention baseline \(s\). Under the corresponding parallel-untreated-trends condition for each post time, each contrast identifies the treated group’s effect at that time. An average over post-intervention times can summarize a period, but it should be defined explicitly: it is an average of the time-specific effects, with the chosen time weights.
Worked Example: Contrasts Across Two Post-Intervention Times
In a hypothetical evaluation, an outcome is measured in units per 1,000 residents. At baseline, the treated group’s mean is 100 and the control group’s mean is 80. At the first and second post-intervention times, the treated means are 108 and 111; the corresponding control means are 84 and 86. Assume the intervention is absent at baseline, the control remains untreated, and untreated changes would have been comparable at each post time.
At the first post-intervention time, the treated group increases by \(108-100=8\) units per 1,000, while the control group increases by \(84-80=4\). The contrast is
At the second post-intervention time, the changes are \(111-100=11\) and \(86-80=6\). The contrast is
The estimated effects are therefore 4 units per 1,000 at the first post time and 5 units per 1,000 at the second, conditional on the stated assumptions. If the target is the equally weighted average effect across these two times, the estimate is
This average is not automatically the effect at either individual time. It answers a different question: the average effect across the two specified post-intervention measurements.
What Pre-Intervention Trajectories Can and Cannot Show
Multiple pre-intervention observations are useful because they allow investigators to inspect whether treated and control outcomes were changing comparably before intervention. Similar pre-intervention changes support the plausibility of the identifying assumption, while pronounced differences raise concern. But observed pre-intervention similarity cannot prove that the groups’ unobserved changes would have remained comparable after the intervention date. A new group-specific shock can arise later, and pre-intervention data cannot rule it out.
Nor does the condition require equal pre-intervention outcome levels. For example, a treated group can have a mean outcome consistently above the control group and still satisfy parallel untreated trends if the gap would have remained stable in the absence of intervention. Conversely, similar levels at baseline do not guarantee comparable future changes.
The identifying claim is specific to the interval and comparison being used. If untreated trends differ over a longer horizon, a contrast over that horizon may fail even if a shorter-interval contrast is plausible. Researchers should therefore state the baseline, post-intervention period, outcome scale, target effect, and substantive basis for treating the control trajectory as a counterfactual for the treated group.
Common Mistakes
- Wrong reasoning: “The groups began at different levels, so the comparison is invalid.” The CITS contrast subtracts changes, not levels. Different baseline levels are allowed when the identifying claim about untreated changes is reasonable.
- Wrong reasoning: “The outcome changed after intervention, so the intervention caused the change.” A before-and-after change includes secular movement and other events. The control change is subtracted to address shared movement, and causal interpretation still requires the assumptions stated above.
- Wrong reasoning: “The pre-intervention lines look similar, so parallel trends is proven.” Similar observed pre-intervention changes are evidence relevant to plausibility, not proof about the unobserved post-intervention counterfactual.
- Wrong reasoning: “The control increased by four units, so the treated group would certainly have increased by four units.” That is the substantive counterfactual assumption, not an arithmetic fact. A treated-specific concurrent shock or a different untreated trend would break it.
Check Your Understanding
Try these questions before reviewing the definitions and examples.
- A treated group changes from 70 to 75 outcome units, while a control group changes from 60 to 62. Calculate the CITS contrast and state its units in context.
- Does the parallel-untreated-trends condition require the treated and control groups to have equal baseline outcome levels? Explain.
- In potential-outcomes terms, what unobserved change does the control group help represent for the treated group?
- Why can a shock that affects only the treated group at the intervention date invalidate the causal interpretation of the contrast?
- What can similar pre-intervention trajectories contribute to an assessment, and what can they not establish?